Recently, Associate Prof. Wang Zhanqi from Zhejiang Provincial Key Laboratory of Vector Biology and Pathogen Control, School of Life Sciences of our University, made innovative progress in the study of Procambarus clarkii’s response to copper stress. With him as the first author and our university as the first unit, the paper entitled “Integrated comparative transcriptome and weighted gene co-expression network analysis provide valuable insights into the response mechanisms of crayfish （Procambarus clarkii） to copper stress” has been carried on the internationally renowned academic Journal “Journal of Hazardous Materials” （TOP q1 Chinese Academy of Sciences, IF: 14.22） Also involved in this work are graduate students Yang Lianlian, Prof. Wang Hua, Prof. Zhang Liqin, Prof. Wu Choufei, Associate Prof. Yi Shaokui, Associate Researcher Gao Quanxin from the School of Life Sciences, as well as Dr. Zhou Fan from Zhejiang Aquatic Technology Extension Station and Prof. Zhang Lixia from Henan Normal University.

　　Copper （Cu） is a biocumulative heavy metal and a widespread environmental pollutant in aquatic ecosystems. Crayfish are an important freshwater aquaculture species that can adapt to a variety of environmental stresses, including heavy metal stress, and their hepatopancreas are considered to be important heavy metal detoxification organs. However, the molecular mechanism of hepatopancreas response to copper stress is still unclear. In this study, comparative transcriptomics, weighted gene co-expression network analysis （WGCNA） and quantitative fluorescence PCR （qPCR） were used to analyze the molecular mechanism of the hepatopancreas in response to copper stress in Procambarus krei. The results of this study can provide new insights into the response of Procambarus clarkii to copper stress, and provide a necessary theoretical basis for its resistance breeding.

　　Thesis information：

　　Wang Z., Yang L., Zhou F., Li J., Wu X., Zhong X., Lv H., Yi S., Gao Q., Yang Z., Zhao P., Wu Y., Wu C., Zhang L., Wang H., Zhang L. Integrated comparative transcriptome and weighted gene co-expression network analysis provide valuable insights into the response mechanisms of crayfish （Procambarus clarkii） to copper stress. Journal of Hazardous Materials, 2023, 448, 130820.

　　Thesis link：https://www.sciencedirect.com/science/article/abs/pii/S0304389423001024

　　Correspondent：Jiang Lu